Adjunctive Clonazepam for Maintenance Treatment of Bipolar Affective Disorder
作者:
GARY SACHS,
JERROLD ROSENBAUM,
LAURA JONES,
期刊:
Journal of Clinical Psychopharmacology
(OVID Available online 1990)
卷期:
Volume 10,
issue 1
页码: 42-47
ISSN:0271-0749
年代: 1990
出版商: OVID
数据来源: OVID
摘要:
In light of the reported efficacy of clonazepam in treating acute mania, we conducted a retrospective review of clinical experience with this agent in maintenance treatment of patients with bipolar affective disorder. Twenty patients with bipolar affective disorder treated with adjunctive clonazepam were identified. A case vignette and summary data on all 20 patients are presented. Clonazepam had been prescribed, in a manner similar to neuroleptics, as part of the maintenance regimen and/or on an as needed basis for acute exacerbations. In six of 17 patients previously receiving combined lithium and neuroleptic treatment, clonazepam successfully replaced the neuroleptic. Overall, eight patients were rated much improved or very much improved, including three of the five cases initially rated most severely ill. Possible mechanisms and treatment strategies are discussed.
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