Pharmacological modification of eye growth in normally reared and visually deprived chicks
作者:
CrewtherD. P.,
CrewtherS. G.,
期刊:
Current Eye Research
(Taylor Available online 1990)
卷期:
Volume 9,
issue 8
页码: 733-740
ISSN:0271-3683
年代: 1990
DOI:10.3109/02713689008999568
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Regular injections of the gliotoxins D-α-aminoadipic acid and L-α-aminoadipic acid were made into the vitreous chamber of the eyes of newly-hatched chicks reared either in a normal visual environment or under conditions of monocular occlusion. Striking differences in the growth rates of the eyes from the different groups were observed. Injection of D-α-aminoadipic acid, which causes the Müller glial cells to swell and diminishes the retinal OFF-response, resulted in a marked increase in the rate of axial growth of the eye compared with normal eyes. However, injection of D-α-aminoadipic acid into occluded eyes caused a lesser growth rate than was observed in occluded control eyes. By contrast, injection of L-α-aminoadipic acid, which also causes severe glial swelling and abolishes the retinal ON-response, caused reduced eye growth in non-occluded eyes. However, injection of L-α-aminoadipic acid into occluded eyes caused eye growth in excess of that recorded in the occluded controls. We concluded that the different growth rates observed is more likely a result of the disruption of the neural ON and OFF mechanisms than of the indisposition of the Müller cells.
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