Synthesis of peptide aldehydes
作者:
Aline Moulin,
Jean Martinez,
Jean‐Alain Fehrentz,
期刊:
Journal of Peptide Science
(WILEY Available online 2007)
卷期:
Volume 13,
issue 1
页码: 1-15
ISSN:1075-2617
年代: 2007
DOI:10.1002/psc.787
出版商: John Wiley&Sons, Ltd.
关键词: peptide aldehydes;synthesis in solution;SPPS;epimerization
数据来源: WILEY
摘要:
AbstractThe functionalization of peptides and proteins by aldehyde groups has become the subject of intensive research since the discovery of the inhibition properties of peptide aldehydes towards various enzymes. Furthermore, peptide aldehydes are of great interest for peptide backbone modification or ligation reactions. This review focuses upon their synthesis, which has been developed following two main strategies. The first strategy consists of prior synthesis of the peptide, followed by the introduction of the aldehyde function. The second possible strategy uses α‐amino aldehydes as starting materials. After protection of the aldehyde, peptide elongation occurs. At the end of the synthesis, the aldehyde function can be unmasked. Copyright © 2006 European Peptide Society and John Wiley&Sons,
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