Time for Phenytoin Concentration to PeakConsequences of First‐Order and Zero‐Order Absorption
作者:
&NA;,
期刊:
Therapeutic Drug Monitoring
(OVID Available online 1989)
卷期:
Volume 11,
issue 5
页码: 540-542
ISSN:0163-4356
年代: 1989
出版商: OVID
关键词: Phenytoin peak time;First-order versus zero-order absorption.
数据来源: OVID
摘要:
An increase in the time required to achieve the peak plasma concentration is observed following the oral administration of increasing doses of phenytoin. Zero-order absorption is the usual explanation for this observation. The presence of Michaelis-Menten elimination also increases the peak time when absorption is first order. The contribution of each of these mechanisms in vivo is unknown.
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