Bayesian Estimation of Fish Disease Prevalence from Pooled Samples Incorporating Sensitivity and Specificity
作者:
Christopher J. Williams,
Christine M. Moffitt,
期刊:
AIP Conference Proceedings
(AIP Available online 1903)
卷期:
Volume 659,
issue 1
页码: 39-52
ISSN:0094-243X
年代: 1903
DOI:10.1063/1.1570533
出版商: AIP
数据来源: AIP
摘要:
An important emerging issue in fisheries biology is the health of free‐ranging populations of fish, particularly with respect to the prevalence of certain pathogens. For many years, pathologists focused on captive populations and interest was in the presence or absence of certain pathogens, so it was economically attractive to test pooled samples of fish. Recently, investigators have begun to study individual fish prevalence from pooled samples. Estimation of disease prevalence from pooled samples is straightforward when assay sensitivity and specificity are perfect, but this assumption is unrealistic. Here we illustrate the use of a Bayesian approach for estimating disease prevalence from pooled samples when sensitivity and specificity are not perfect. We also focus on diagnostic plots to monitor the convergence of the Gibbs‐sampling‐based Bayesian analysis. The methods are illustrated with a sample data set. © 2003 American Institute of Physics
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