The Effect of Thyrotropin-Releasing Hormone (TRH) and Somatostatin (GHRIH) on Growth Hormone and Prolactin Secretionin vitroandin vivoin the Domestic Fowl (Gallus domesticus)
作者:
S. Harvey,
C.G. Scanes,
A.C. Chadwick,
N.J. Bolton,
期刊:
Neuroendocrinology
(Karger Available online 1978)
卷期:
Volume 26,
issue 4
页码: 249-260
ISSN:0028-3835
年代: 1978
DOI:10.1159/000122831
出版商: S. Karger AG
关键词: Pituitary;Thyrotropin-releasing hormone;Growth hormone release inhibitory hormone;GH and Prl responses;Chickens
数据来源: Karger
摘要:
The effects of thyrotropin-releasing hormone (TRH) on growth hormone (GH) and prolactin (Prl) secretion have been investigated in vitro and in vivo in domestic fowl. In both conscious and anaesthetized immature chickens the administration (i.v.) of TRH (2.5 and 25 μg/kg) significantly increased the concentration of plasma GH. The simultaneous administration of somatostatin (GHRIH), 2.5 μg/kg, to conscious birds significantly reduced the magnitude of the GH response to TRH treatment, but had no effect on the basal levels of plasma GH. The repeated injection of TRH (10 μg/kg) every 20 min over a 100-min period failed to maintain the concentration of plasma GH at a high level. Prl secretion was not stimulated in any of these experiments, and in anaesthetized birds TRH (2.5 and 25 μg/kg) treatment was followed by a depression in the level of plasma Prl. The effects of TRH and GHRIH on GH secretion by an in vitro dispersed pituitary cell suspension system were very similar to the in vivo studies. TRH stimulated Prl release in vitro, in contrast to the in vivo studies, and the response was dose related. GHRIH had no effect on the basal release of Prl in vitro but significantly inhibited the response to TRH treatm
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