Modulation of Pulsatile LH Secretion by Baclofen, a Selective GABABReceptor Agonist, in Ovariectomized Rats
作者:
Tatsuo Akema,
Fukuko Kimura,
期刊:
Neuroendocrinology
(Karger Available online 1992)
卷期:
Volume 56,
issue 2
页码: 141-147
ISSN:0028-3835
年代: 1992
DOI:10.1159/000126221
出版商: S. Karger AG
关键词: γ-Aminobutyric acid;GABAB receptor;Baclofen;Luteinizing hormone;Pulsatile secretion
数据来源: Karger
摘要:
The effect of activation of central γ-aminobutyric acid β (GABAB) receptors on pulsatile luteinizing hormone (LH) secretion was examined in unanesthetized ovariectomized rats. Intraventricular injections of 2 or 10 µg baclofen, a selective GABAB receptor agonist, usually arrested the existing pulsatile LH secretion for a short period, then LH pulses resumed with reduced frequencies and increased amplitudes. The increase in the pulse amplitude was not necessarily accompanied by a reduction in the pulse frequency, but was observed even after nonelongated interpulse intervals in animals receiving the GABA agonist. Mean LH levels showed complex bi- and triphasic fluctuations after the central administration of high and low doses of baclofen, respectively. It was concluded that central GABAB receptors are involved in the modulatory mechanism affecting the LH pulse frequency and amplitude in the ovariectomized r
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