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Dermal absorption of the insecticide lindane (1δ, 2δ, 3β, 4δ, 5...
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Dermal absorption of the insecticide lindane (1δ, 2δ, 3β, 4δ, 5δ, 6β‐hexachlorocyclohexane) in rats and rhesus monkeys: Effect of anatomical site
作者:
RichardP. Moody,
Leonard Ritter,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1989)
卷期:
Volume 28,
issue 2
页码: 161-169
ISSN:0098-4108
年代: 1989
DOI:10.1080/15287398909531337
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Dermal absorption of the insecticide lindane (1δ, 2δ, 3β, 4b, 5δ, 6β‐hexachlorocyclo‐hexane) was determined in rats and rhesus monkeys. Lindane is in widespread use as a 1% cream or lotion scabicide formulation and as a 1% miticide shampoo for body lice control in humans. Results obtained following our in vivo dermal absorption procedure demonstrated that 18 ± 4.1%, 34 ± 5.2%, and 54 ± 26.3% of the applied dose was absorbed following topical applications at a rate of 1.5 μg/cm2(6.2 μg/100 μl of acetone) of the14C‐labeled pesticide to 4.2‐cm2regions of the forearm (n= 8), forehead (n= 7), and palm (n= 4) of rhesus monkeys, respectively. Dose sites were washed with soapy water 24 h posttreatment. Comparative studies in rats (n= 5) dosed middorsally demonstrated 31 ± 9.5% absorption. Statistical analysis of the14C excretion kinetics demonstrated slower clearance of lindane from rats than monkey forearm, forehead, or palm. Intramuscular (im) injections of14C‐lindane gave 52 ± 7.1% recovery in monkey (n= 8) and 64 ± 5.9% in rats (n= 5), suggesting body storage of this lipophilic chemical.
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