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Dopamine markers and general cognitive ability

 

作者: David Ball,   Linzy Hill,   Thalia Eley,   Michael Chorney,   Karen Chorney,   Lee Thompson,   Douglas Detterman,   Camilla Benbow,   David Lubinski,   Michael Owen,   Peter McGuffin,   Robert Plomin,  

 

期刊: NeuroReport  （OVID Available online 1998）
卷期: Volume 9, issue 2  

页码: 347-349

 

ISSN:0959-4965

 

年代: 1998

 

出版商: OVID

 

关键词: Allelic association;Dopamine;General cognitive ability;Intelligence;Polymorphisms

 

数据来源: OVID

 

摘要:

BECAUSE general cognitive ability (g) is among the most heritable behavioural traits, it is a reasonable target for a search for quantitative trait loci (QTLs). We used a selected-extremes design to test candidate genes for allelic association withg. Polymorphisms in four genes in the dopamine system (DRD2, DRD3, DRD4, DAT1) were genotyped for 51 highgchildren with IQ scores > 130 and for 51 averagegcontrol children. No significant allelic or genotypic differences were found between the highgand averageggroups for these markers of the dopamine system, even though the selected-extremes design provides power to detect QTL associations that involve a relative risk of about 1.5.

 

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