Fitting a biological rhythm to a synchronizer: Applied illustration of mouse activity rhythms in genetic analysis
作者:
Jacques Beau,
期刊:
Journal of Interdisciplinary Cycle Research
(Taylor Available online 1991)
卷期:
Volume 22,
issue 3
页码: 271-280
ISSN:0022-1945
年代: 1991
DOI:10.1080/09291019109360111
出版商: Taylor & Francis Group
关键词: Chronobiology;circadian rhythm;synchronizer;correlation;heterosis
数据来源: Taylor
摘要:
The D/L ratio, which expresses amount of activity during the dark part of the cycle over amount cf activity during the light part of this cycle can serve as a mesure of rhythm contrast: it indicates whether there is a sharp dichotomy between the activity phase and the resting phase. The drawback to this parameter is that it is highly responsive to phase. The solution is to define the active and resting phases in terms of a synchronizer type function which maximizes its intercorrelation with the target rhythm. This function can then be used to define the Active and Resting phases to compute a new, phase‐independant A/R index. Furtermore, the intercorrelation function value is also a measure the best fit of the rhythm to its synchronizer. An example of application of these methods is presented for inbred strains of mice C57BL/6 and BALB/c and their reciprocal Fls. Obtained heterosis effects indicate that the Fl rhythm fits the synchronizer better than the rhythm of the parental strains.
点击下载:
PDF (495KB)
返 回