Endothelin-1 Levels in the Maternal-Fetal Dyad
作者:
Luis A. Bracero,
Mario R. Reale,
Minda N. Te,
Guillermo A. Zeballos,
Harry S. Dweck,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1995)
卷期:
Volume 39,
issue 4
页码: 221-225
ISSN:0378-7346
年代: 1995
DOI:10.1159/000292414
出版商: S. Karger AG
关键词: Endothelin-1;Pregnancy;Umbilical vessels;Newborns
数据来源: Karger
摘要:
The aim of this study was to determine the distribution of ET-1 levels in the term maternal-fetal dyad. We also compared the levels of ET-1 between umbilical vessels and assessed the effect of labor on the concentration of ET-1. The ET-1 levels were measured in plasma from 18 term maternal-infant pairs. Amniotic fluid ET-1 levels were also measured in 9 of these pregnancies. The ET-1 levels were determined by radioimmunoassay (RIA) after extraction of plasma using Sep-Pak C18 cartridges. There were no significant differences in the ET-1 levels between the umbilical artery and vein. However, there were significant differences in the umbilical artery concentration in women who labored when compared with those delivered without labor (6.0 ± 1.1 vs. 2.7 ± 0.7 pg/ml; t test, p = 0.022). ET-1 levels were lowest in the maternal plasma (0.9 ± 0.2 pg/ml) and highest in the amniotic fluid (83 ± 15 pg/ml). Assuming that elevated plasma ET-1 levels reflect increased bioactivity, the higher mean ET-1 levels in the cord vessels and in the amniotic fluid when compared to maternal levels suggest a role for ET-1 in the regulation of the fetoplacental circulation and in the constriction of blood vessels in the uterus after parturition. The higher levels of ET-1 in the umbilical artery of women who underwent labor implies that ET-1 is released as a result of the stress of labor.
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