A critical role for ACAID in the distinctive pattern of retinitis that follows anterior chamber inoculation of HSV-1
作者:
StreileinJ. Wayne,
AthertonSally,
VannVince,
期刊:
Current Eye Research
(Taylor Available online 1987)
卷期:
Volume 6,
issue 1
页码: 127-132
ISSN:0271-3683
年代: 1987
DOI:10.3109/02713688709020079
出版商: Taylor&Francis
数据来源: Taylor
摘要:
To test the hypothesis that ACAID induction is instrumental in producing the distinctive pattern of retinal pathology that follows anterior chamber inoculation of HSV-1 in BALB/c mice, panels of mice received uniocular anterior chamber, uniocular intravitreal, and bilateral anterior chamber inoculations of HSV-1. It was found that contralateral retinitis developed after the first two routes, and ACAID was induced by all three. Enucleation of eyes inoculated with HSV-1 before 3 days post-inoculation(but not thereafter) prevented both ACAID and contralateral retinitis. Intracameral inoculations of HSV-2 induced vigorous delayed hypersensitivity and failed to incite contralateral retinitis. It is concluded that ACAID induction plays a crucial role in the pathogenesis of contralateral retinitis following anterior chamber inoculation of HSV-1.
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