Pharmacokinetics and Bioavailability of Methylphenobarbital in Man
作者:
W.,
Hooper H.,
Kunze M.,
期刊:
Therapeutic Drug Monitoring
(OVID Available online 1981)
卷期:
Volume 3,
issue 1
页码: 39-44
ISSN:0163-4356
年代: 1981
出版商: OVID
关键词: Mephobarbital;Phenobarbital;Metabolism;Pharmacokinetics;Bioavailability
数据来源: OVID
摘要:
The pharmacokinetics and bioavailability of mephobarbital have been studied in 2 volunteers. Plasma levels of mephobarbital and phenobarbital were measured by gas chromatography-mass spectroscopy with selected ion monitoring. Urinary output of phenobarbital and thep-hydroxy derivatives of both mephobarbital and phenobarbital was measured by high pressure liquid chromatography. The time course of these plasma and urinary levels was monitored following single 800-mg oral and 200-mg intravenous doses in the 2 patients. The major conclusions of the study were that mephobarbital is reasonably well absorbed following oral dosing and that some 35% or so of the dose (by either route) is converted to the recently identified metabolite,p-hydroxymephobarbital.
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