首页   按字顺浏览 期刊浏览 卷期浏览 A Transmission Disequilibrium Test for Quantitative Trait Loci
A Transmission Disequilibrium Test for Quantitative Trait Loci

 

作者: Daniel Rabinowitz,  

 

期刊: Human Heredity  (Karger Available online 1997)
卷期: Volume 47, issue 6  

页码: 342-350

 

ISSN:0001-5652

 

年代: 1997

 

DOI:10.1159/000154433

 

出版商: S. Karger AG

 

关键词: Genetic linkage analysis;Haplotype relative risk;Transmission disequilibrium

 

数据来源: Karger

 

摘要:

The transmission disequilibrium test uses association between marker alleles and dichotomous traits for precise genetic mapping while avoiding confounding due to population admixture. Here, the methodology is generalized from dichotomous traits to quantitative traits. The generalization is computationally straightforward and may be used with multiple alleles and with siblings. Parametric assumptions on the distribution of the quantitative traits are not needed. Environmental and demographic covariates may be incorporated into the analysis. The results of simulation studies that provide information about the power of the approach are reported.

 

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