A Transmission Disequilibrium Test for Quantitative Trait Loci
作者:
Daniel Rabinowitz,
期刊:
Human Heredity
(Karger Available online 1997)
卷期:
Volume 47,
issue 6
页码: 342-350
ISSN:0001-5652
年代: 1997
DOI:10.1159/000154433
出版商: S. Karger AG
关键词: Genetic linkage analysis;Haplotype relative risk;Transmission disequilibrium
数据来源: Karger
摘要:
The transmission disequilibrium test uses association between marker alleles and dichotomous traits for precise genetic mapping while avoiding confounding due to population admixture. Here, the methodology is generalized from dichotomous traits to quantitative traits. The generalization is computationally straightforward and may be used with multiple alleles and with siblings. Parametric assumptions on the distribution of the quantitative traits are not needed. Environmental and demographic covariates may be incorporated into the analysis. The results of simulation studies that provide information about the power of the approach are reported.
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