AbstractMultivoxel 3D localized proton spectroscopy using a hybrid of 1D 8th‐order transverse Hadamard spectroscopic imaging (HSI) with 2D chemical shift imaging (CSI) is demonstrated in human brain. The spatially selective HSI pulse incorporates naturally into the PRESS sequence (TE= 135 ms), which then both excites an 8 × 8 × 6 cm parallelepiped volume of interest (VOI) and subdivides it into eight slices. The planes of these slices are further partitioned into 16 × 16 voxel arrays using 2D CSI to yield 8 × 8 × 8 voxels within the VOI. Simultaneous 3D coverage yields good voxel signal‐to‐noise (8, 12, and 22 for choline, creatine, andN‐acetylaspartate, respectively) from these 0.75‐ml voxels, in ˜45 min. The high spatial isolation allows localization to within less than 1 cm from the skull without fa