Overexpression of C-kit in a Leukemic Cell Population Carrying a Trisomy 4 and its Relationship with the Proliferative Capacity
作者:
FerrariSergio,
GrandeAlexis,
ZucchiniPatrizia,
ManfrediniRossella,
TagliaficoEnrico,
RossiElena,
TemperaniPaola,
TorelliGiuseppe,
EmiliaGiovanni,
TorelliUmberto,
期刊:
Leukemia&Lymphoma
(Taylor Available online 1993)
卷期:
Volume 9,
issue 6
页码: 495-501
ISSN:1042-8194
年代: 1993
DOI:10.3109/10428199309145756
出版商: Taylor&Francis
关键词: c-kit;stem cell factor;acute leukemia;proliferation;oncogene;cytokines
数据来源: Taylor
摘要:
The expression of c-kit and its ligand, the stem cell factor (SCF), was studied in five cases of acute myeloid leukemia. One of these had a trisomy of chromosome 4, where the c-kit oncogene is located. In this case, the c-kit oncogene was overexpressed, but matched by a low expression of its ligand, SCF. The molecular evaluation of the growth rate by c-myc and the histone H3 expression indicated that the growth fraction of this cell population was very low. In one of the other leukemic cell populations studied, characterized by a low expression of c-kit and an elevated expression of the SCF, the growth fraction was also very low. Our results suggest that at least for some receptor oncogenes, the simple overexpression cannot be taken as an indication that the oncogene is involved in the deregulation of cell proliferation.
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