Effects of Labetalol on Hemodynamics and Seizure Duration During ECT
作者:
W. McCall,
Frank Shelp,
Richard Weiner,
Shirley Austin,
Audrey Harrill,
期刊:
Convulsive Therapy
(OVID Available online 1991)
卷期:
Volume 7,
issue 1
页码: 5-14
ISSN:0749-8055
年代: 1991
出版商: OVID
关键词: Labetalol;Heart rate;Blood pressure
数据来源: OVID
摘要:
Beta blockers are commonly used to attenuate the transient increase in heart rate (HR) and blood pressure (BP) that accompany electrocon-vulsive therapy (ECT). Recent reports have suggested that several beta blockers have anticonvulsant properties and hence could be countertherapeutic with ECT. In a randomized, double-blind controlled study of the dose response effects of intravenous labetalol on ECT hemodynamics and seizure duration, labetalol exhibited dose-dependent reduction in HR and rate pressure product (RPP) at the 5 and 10 mg doses compared to placebo. However, no significant differences between labetalol 5 mg, 10 mg, or placebo were found on BP or seizure duration.
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