Melatonin, Its Receptors, and Relationships with Biological Rhythm Disorders
作者:
P. Delagrange,
B. Guardiola-Lemaitre,
期刊:
Clinical Neuropharmacology
(OVID Available online 1997)
卷期:
Volume 20,
issue 6
页码: 482-510
ISSN:0362-5664
年代: 1997
出版商: OVID
关键词: Humans;Treatment;Circadian rhythms.
数据来源: OVID
摘要:
Summary:Melatonin is a neurohormone produced during the night by the pineal gland. Its secretion is regulated by circadian and seasonal variations in daylength, transmitted via visual projections to the suprachiasmatic nucleus which functions as a circadian clock in mammals. Melatonin has been proposed to act as an internal synchronizer of circadian rhythms generated at different levels of the organism. The chronobiotic effects of melatonin in humans have been mainly studied in circadian rhythm sleep disorders related to jet lag, shift work, blindness or aging. Alterations of the melatonin profiles have also been reported in other biological rhythm disorders.
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