Myofascial pain syndrome (MPS) is one of the least understood yet commonly encountered problems In the outpatient setting. Myofascial pain syndrome is a painful disorder characterized by trigger points (TrPs), which are hyperirritable spots causing referred pain. Myofascial pain syndrome is frustrating to patients and clinicians. Unfortunately, MPS often goes unrecognized, misdiagnosed, or mistreated, leading to unnecessary pain, suffering, and disability. When treated properly, MPS has an excellent prognosis. Besides specific TrP therapy, treatment involves lifestyle changes and long-term management to prevent recurrences. A multidisciplinary approach utilizing primary care providers, physical therapists, occupational therapists, and other health care professionals is essential to correctly assess and treat MPS. Primary care providers knowledgeable about MPS are in a pivotal position to identify this disorder and to intervene appropriately.