PREVENTION OF CYTOMEGALOVIRUS‐RELATED DEATH BY PASSIVE IMMUNIZATIONA DOUBLE‐BLIND PLACEBO‐CONTROLLED STUDY IN KIDNEY TRANSPLANT RECIPIENTS TREATED FOR REJECTION
作者:
H. METSELAAR,
P. ROTHBARTH,
R. BROUWER,
G. WENTING,
J. JEEKEL,
W. WEIMAR,
期刊:
Transplantation
(OVID Available online 1989)
卷期:
Volume 48,
issue 2
页码: 264-265
ISSN:0041-1337
年代: 1989
出版商: OVID
数据来源: OVID
摘要:
In a double-blind placebo-controlled study, the value of prophylactic anti-CMV immunoglobulin administration was evaluated in 39 kidney transplant recipients treated for rejection with rabbit antithymocyte globulin. Passive immunization completely prevented CMV-related death, although it did not reduce the incidence of CMV isolation, viremia, or disease.The effect of passive immunization was exclusively observed in CMV-seronegative recipients of a CMV-seropositive kidney donor. It could be demonstrated even when instituted when antirejection therapy was started. Seropositive recipients did not benefit from immunoglobulin treatment. Moreover, CMV-seronegative recipients of a kidney from a seronegative donor were not at risk for CMV infection at all. Therefore passive immunization should be restricted to seronegative recipients of seropositive allograft donors treated for rejection.
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