In vitroandin vivoStudies of the Action of Rifampicin, Clofazimine and B1912 onMycobacterium marinum
作者:
D.K. Banerjee,
I.B. Holmes,
期刊:
Chemotherapy
(Karger Available online 1976)
卷期:
Volume 22,
issue 3-4
页码: 242-252
ISSN:0009-3157
年代: 1976
DOI:10.1159/000221931
出版商: S. Karger AG
关键词: Mycobacterium marinum;Mouse footpad infection;Rifampicin;Clofazimine (B663);B1912;Bactericidal action
数据来源: Karger
摘要:
Rifampicin (RMP) and two riminophenazine compounds (B663 and B1912) suppressed the growth of Mycobacterium marinumin vitro and in a mouse footpad infection. At appropriate concentrations and dietary dosage, all three drugs showed bactericidal activity in vitro and in vivo. On the basis of minimum inhibitory concentration, RMP was considerably more active than the other two substances in vitro. However, the rate of bactericidal effect was similar for all three drugs. In vivo, the minimum bactericidal dietary dosages of RMP, B663 and B1912 were 0.03, 0.03 and ≤0.01 %, respectively. Results suggest that these drugs may be of value for the treatment of clinical M. marinum infection
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