Guanosine Potentiates the Antiproliferative Effect of Cytosine-β-D-Arabinofuranoside in Melanoma Cell Lines
作者:
SidiY.,
PanetC.,
CyjonA.,
FenigE.,
BeeryE.,
NordenbergJ.,
期刊:
Cancer Investigation
(Taylor Available online 1993)
卷期:
Volume 11,
issue 5
页码: 523-529
ISSN:0735-7907
年代: 1993
DOI:10.3109/07357909309011670
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Guanosine is shown to potentiate markedly the antiproliferative effect of cytosine-β-D-arabinoside (ara-C) on B16 F10 mouse and SKMEL-28 human melanoma cell lines. Several metabolic consequences of the synergistic interaction between ara-C and guanosine on cell growth were determined in BI6 F10 mouse melanoma cells. Treatment of the cells with guanosine for 24hr resulted in an increase in the percentage of cells in the S phase of the cell cycle, a threefold increase in intracellular GTP concentration, and an increase in the incorporation of ara-C into acid-insoluble material and phosphorylated metabolites. These findings suggest that guanosine potentiates the growth-inhibitory effect of ara-C in B16 F10 melanoma cells by increasing the intracellular concentration of its active metabolites.
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