Phenytoin removal during plasma exchange
作者:
Roger L. White,
William R. Garnett,
Jody H. Allen,
Berry J. Kline,
David E. Sharp,
期刊:
Journal of Clinical Apheresis
(WILEY Available online 1987)
卷期:
Volume 3,
issue 3
页码: 147-150
ISSN:0733-2459
年代: 1987
DOI:10.1002/jca.2920030303
出版商: John Wiley&Sons, Inc.
关键词: plasmapheresis;anticonvulsant;drug monitoring
数据来源: WILEY
摘要:
AbstractPlasma exchange is currently being used to treat a variety of disorders including immune complex and hematologic disorders. It has been shown that the removal of plasma removes drugs bound to plasma proteins. This case documents the removal of phenytoin during plasma exchange therapy. Total and free phenytoin serum concentrations were obtained before and after each exchange. Aliquots were obtained from each pass, and total phenytoin concentrations were determined. The total phenytoin serum concentration increased during the first exchange, while the total concentration decreased as a result of the second exchange. It was determined that approximately 27.7 mg and 30.4 mg of phenytoin were removed by the first and second plasma exchanges, respectively.
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