Lithium‐Induced Creutzfeldt‐Jakob Syndrome
作者:
B. Casanova,
M. de Entrambasaguas,
C. Perla,
E. Gómez‐Siurana,
A. Benetó,
J. Burguera,
期刊:
Clinical Neuropharmacology
(OVID Available online 1996)
卷期:
Volume 19,
issue 4
页码: 356-359
ISSN:0362-5664
年代: 1996
出版商: OVID
关键词: Creutzfeldt‐Jakob syndrome;Lithium;Bipolar disorder;Drug toxicity.
数据来源: OVID
摘要:
Summary:A 67‐year‐old man with bipolar disorder developed a Creutzfeldt‐Jakob like syndrome during lithium carbonate treatment. Lithium serum level was within the therapeutic range. Complete clinical‐electroencephalographic recovery was achieved after lithium therapy was discontinued. Several cases of lithium‐induced Creutzfeldt‐Jakob syndrome have been reported to date; all of them were elderly patients and a half had “therapeutic” lithium serum levels. Patients in this age group receiving antimanic maintenance treatment should keep lithium serum levels as low as possible. Lithium neurotoxicity should be considered in Creutzfeldt‐Jakob disease differential diagnosis, serial electroencephalograms being the most valuable.
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