Inhibition of Luteinizing Hormone Release and Ovulation by 6-Chloro- and 6-Fluoromelatonin
作者:
James A. Clemens,
Michael E. Flaugh,
John Parli,
Barry D. Sawyer,
期刊:
Neuroendocrinology
(Karger Available online 1980)
卷期:
Volume 30,
issue 2
页码: 83-87
ISSN:0028-3835
年代: 1980
DOI:10.1159/000122980
出版商: S. Karger AG
关键词: 6-Chloromelatonin;Fluoromelatonin;Melatonin;Prolactin;Luteinizing hormone
数据来源: Karger
摘要:
The effects of 6-chloromelatonin and 6-fluoromelatonin on ovulation and LH and prolactin release in rats were determined. Both halogenated melatonin analogs were more potent ovulation blockers than melatonin. The halogenated melatonin analogs inhibited the ovulatory surge of luteinizing hormone (LH) but did not alter the proestrous prolactin surge, nor did they alter basal serum levels of LH or prolactin. The plasma half-life of 6-chloromelatonin in rats and rhesus monkeys was 27 min compared to 11 min for melatonin. The results indicate that 6-chloromelatonin is a melatonin agonist with greater metabolic stability than melatonin.
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