PRESENCE AND STABILITY OF GASTRIN IN THE GASTRIC JUICE OF THE FETAL SHEEP
作者:
Arthur Shulkes,
Patricia Chick,
Kenneth J. Hardy,
期刊:
Clinical and Experimental Pharmacology and Physiology
(WILEY Available online 1984)
卷期:
Volume 11,
issue 1
页码: 45-52
ISSN:0305-1870
年代: 1984
DOI:10.1111/j.1440-1681.1984.tb00238.x
出版商: Blackwell Publishing Ltd
关键词: fetal growth;gastric juice;gastrin
数据来源: WILEY
摘要:
SUMMARY1. Although gastrin is found in adult gastric juice, rapid enzymatic destruction by pepsin in the acid environment makes a physiological role in the adult unlikely.2. Gastric pH in the fetal sheep is neutral so that gastric juice gastrin could be present, and if present, have a physiological function.3. The aim of this study was to determine the presence, molecular forms and metabolism of gastrin in gastric juice.4. Gastrin was present in fetal gastric juice at significantly higher concentrations than in fetal plasma.5. The majority of gastric juice gastrin was present as the biologically active gastrin‐17.6. Gastrin was stable in normal fetal gastric juice, but was rapidly metabolized to smaller C‐terminal fragments when the gastric juice was acidified.7. With the known growth promoting effect of gastrin on gastrointestinal mucosa, gastrin in fetal juice could have a unique role in thein uterodevelopment of the gastrointestinal tr
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