Release of High Molecular Weight Neutrophil Chemotactic Activity from Human Cultured Basophilic Cells
作者:
Toshikazu Nagakura,
Kozaburo Shichijo,
Yoji Likura,
Miyuki Kobayashi,
Hirohisa Saito,
Takeshi Otani,
期刊:
Pediatrics International
(WILEY Available online 1987)
卷期:
Volume 29,
issue 5
页码: 663-666
ISSN:1328-8067
年代: 1987
DOI:10.1111/j.1442-200X.1987.tb00356.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
AbstractWe have shown that cultured basophilic cells, derived from human cord blood cells, release histamine and high molecular weight neutrophil chemotactic activity (HMW‐NCA), in a dose‐dependent manner following calcium ionophore and anti‐IgE challenge. The HMW‐NCA detected from human cultured basophilic cells had a similar molecular weight to that of human chopped lung challenged by anti‐IgE as determined by gel filtration chromatography. These results suggest that cultured basophilic cells might be employed for research into the chemical mediators involved in immediate hyperse
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