Plasma Concentrations of Carbamazepine and Carbamazepine 10,11-Epoxide During Pregnancy and After Delivery
作者:
D. Battino,
S. Binelli,
L. Bossi,
R. Canger,
D. Croci,
C. Cusi,
M. De Giambattista,
G. Avanzini,
期刊:
Clinical Pharmacokinetics
(ADIS Available online 1985)
卷期:
Volume 10,
issue 3
页码: 279-284
ISSN:0312-5963
年代: 1985
出版商: ADIS
数据来源: ADIS
摘要:
Plasma concentrations of carbamazepine were monitored in 9 pregnant epileptic patients treated with the drug alone at constant doses during pregnancy and for at least 3 months after delivery. In addition, plasma concentrations of the metabolite. carbamazepine 10, 11-epoxide were measured in 6 of the 9 patients. Plasma carbamazepine concentrations were fairly stable during pregnancy, and carbamazepine relative plasma clearances were significantly higher in weeks 4 to 24 than in weeks 25 to 32. After the end of the second trimester, there were no variations in plasma carbamazepine 10.11-epoxide concentrations and carbamazepine 10.11-epoxide : carbamazepine ratios. Both parameters were significantly higher in weeks 4 to 24 than in weeks 25 to 32 of pregnancy.
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