Atomic force microscopy (AFM) and scanning tunneling microscopy (STM) have been successfully used to observe four systems of organic macromolecules; spin‐coated polystyrene; polyethylene oxide; polythiophene and polypyrrole; and phosphorylase kinase and phosphorylaseb. Images shown demonstrate the ability of AFM and STM to resolve the structure of these systems with subnanometer resolution. Further discussion supports these two techniques as valuable research tools in this area.