Comparative pharmacokinetics of amoxicillin administered intravenously to sheep and goats
作者:
A. L. CRAIGMILL,
M. A. PASS,
S. WETZLICH,
期刊:
Journal of Veterinary Pharmacology and Therapeutics
(WILEY Available online 1992)
卷期:
Volume 15,
issue 1
页码: 72-77
ISSN:0140-7783
年代: 1992
DOI:10.1111/j.1365-2885.1992.tb00988.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
The pharmacokinetic behavior of sodium amoxicillin was studied after intravenous administration to six sheep and five goats to determine if there are species differences in disposition. The plasma drug concentrations vs. time following intravenous administration of 10 mg/kg were best described by the biexponential equationsCp= 42.9e‐0.077.t+ 3.68e‐0.0134‐tfor goats, andCp= 53.5e‐0.06‐t+ 1.69e‐0.015‐tfor sheep. The terminal disposition half‐lives for sheep and goats were 46.3 and 66.9 min respectively and were not significantly different. Amoxicillin clearance for sheep and goats were 10.1 and 11.4 ml/min.kg respectively. There were no significant differences between any of the pharmacokinetic parameters measured in
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