Seven-Year Follow-Up Study of Bromocriptine Therapy for Parkinson’s Disease
作者:
M. Yanagisawa,
I. Kanazawa,
I. Goto, †,
H. Kowa,
S. Kuno,
Y. Mizuno,
K. Tashiro,
N. Ogawa,
期刊:
European Neurology
(Karger Available online 1994)
卷期:
Volume 34,
issue 3
页码: 29-35
ISSN:0014-3022
年代: 1994
DOI:10.1159/000119539
出版商: S. Karger AG
关键词: Dopamine receptor agonists;Bromocriptine;Neuroprotective therapy;Long-term treatment
数据来源: Karger
摘要:
A 7-year nationwide study of bromocriptine monotherapy and combination therapy with bromocriptine and levodopa in Parkinson’s disease is reported. Of 22 patients who had been on bromocriptine monotherapy for 7 years (group B), 16 remained improved or remained in the same stages of Hoehn and Yahr, and no wearing-off phenomenon or dyskinesia was observed. In another 56 patients who were started on bromocriptine alone, but in whom combination therapy with levodopa was instituted at some time in the 7 years (group BL), disease progressed faster than in group B. A wearing-off phenomenon and dyskinesia occurred in 34% and 5.4% of the patients, respectively. These manifestations appeared only after initiation of levodopa. The favorable course of group B suggests possible neuroprotective effects of bromocriptine or may be due to the inevitable selection of patients who had a favorable course originall
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