Oral mucositis associated with head and neck radiotherapy can substantially hinder completion of cancer therapy. Alleviation of this often severe stomatitis can provide enhanced patient comfort and facilitate appropriate care.A double‐blind format was used in a pilot project to measure, against a control rinse, the effectiveness of an oral rinse consisting of hydrocortisone, nystatin, tetracycline, and diphenhydramine in controlling radiation‐related mucositis. A combination of clinical evaluation and patient responses to a questionnaire was used to judge the results of the topical medications.Patients using the experimental medication developed less mucositis than did patients in the control gr