Opposite effects of the synthetic immunodulator, muramyl dipeptide, on rejection of mouse skin allografts
作者:
Zdeněk Zídek,
Jana Čapková,
Michal Boubelík,
Karel Mašek,
期刊:
European Journal of Immunology
(WILEY Available online 1983)
卷期:
Volume 13,
issue 10
页码: 859-861
ISSN:0014-2980
年代: 1983
DOI:10.1002/eji.1830131015
出版商: WILEY‐VCH Verlag GmbH
数据来源: WILEY
摘要:
AbstractThe influence of muramyl dipeptide (N‐acetylmuramyl‐L‐alanyl‐D‐isoglutamine) on the rejection of mouse skin allografts was investigated. While the 0.1‐mg dose administered on days 7, 6, 5 prior to transplantation caused significant prolongation of the graft survival, the 0.5‐mg dose administered on days 3,2,1 prior to transplantation resulted in remarkable augmentation of the graft rejection. The present results support the view that muramyl dipeptide can induce both stimulatory and suppressive immune mechanisms, depending on the trea
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