Loss of Rt6 Message and Most Circulating T Cells after Thymectomy of Diabetes Prone BB Rats
作者:
SarkarProbir,
CrisáLaura,
McKeeverUna,
BortellRita,
HandlerEugene,
MordesJohn P.,
WaiteDebra,
SchoenbaumAmy,
HaagFriedrich,
NolteFriedrich Koch,
Gunther ThieleHeinz,
GreinerDale L.,
RossiniAldo A.,
期刊:
Autoimmunity
(Taylor Available online 1994)
卷期:
Volume 18,
issue 1
页码: 15-22
ISSN:0891-6934
年代: 1994
DOI:10.3109/08916939409014675
出版商: Taylor&Francis
关键词: BB rat;thymus;RT6;T cell;lymphopenia;ontogeny;autoimmunity
数据来源: Taylor
摘要:
T cells expressing the RT6 surface alloantigcn perform important immunoregulatory functions in the rat. Diabetes prone (DP) BB rats arc deficient in circulating RT6+T cells and develop spontaneous autoimmune diabetes mellitus. Transfusions leading to cngraftment of RT6′T cells prevent the disease. Coisogcnic diabetes resistant (DR) BB rats do circulate RT6^ T cells and are free of disease. We investigated the basis for the deficiency of RT6 * T cells in the DP-BB rat and made the following observations. 1. Thymectomy causes the rapid loss of most peripheral T cells in the DP-BB rat. 2. Concomitant with the loss of T cells is the total loss of mRNA encoding RT6. 3. In contrast to the effects observed in peripheral lymphoid tissues, thymectomy does not lead to a detectable loss in RT6+protein found in the small intestine. We conclude that the deficiency of RT6+peripheral T cells in the DP-BB rat is due either to their short life span or to their reduced proliferative capacity following release from the thymus.
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