Close Relationships between Serotonergic and Fibrinolytic Systems Revealed by a Monoamine Oxidase Inhibitor Treatment in Rats
作者:
Tetsumei Urano,
Jolanta Malyszko,
Yumiko Takada,
Akikazu Takada,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1995)
卷期:
Volume 25,
issue 6
页码: 277-282
ISSN:1424-8832
年代: 1995
DOI:10.1159/000217173
出版商: S. Karger AG
关键词: Tranylcypromine;Serotonin;Fibrinolysis;Tissue plasminogen activator;Plasminogen activator inhibitor
数据来源: Karger
摘要:
In order to investigate a possible relationship between serotonergic and fibrinolytic systems, serotonin (5-hydroxytryptamine, 5-HT) metabolism was modified by the use of a monoamine oxidase inhibitor (tranylcypromine: 10 mg/kg body weight) and its effect on the fibrinolytic system was analyzed. Tranylcypromine caused a rise in whole blood 5-HT with a simultaneous fall in 5-hydroxyindoleacetic acid. Euglobulin clot lysis time was significantly prolonged 1 and 4 h after injection and tissue plasminogen activator (tPA) activity declined 4 h following administration with a simultaneous increase in its inhibitor (PAI) activity. Blood 5-HT was negatively related to tPA (r = -0.48; p < 0.05) and positively to PAI activities (r = 0.43; p < 0.05) in tranylcypromino-treated rats, whereas there were no such correlations in solvent-treated rats.
点击下载:
PDF
(2145KB)
返 回