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Involvement of Central Vasopressin Receptors in the Control of Blood Pressure

 

作者: Mariana Morris,   Larry E. Sain,   Susan J. Schumacher,  

 

期刊: Neuroendocrinology  （Karger Available online 1986）
卷期: Volume 43, issue 5  

页码: 625-628

 

ISSN:0028-3835

 

年代: 1986

 

DOI:10.1159/000124591

 

出版商: S. Karger AG

 

关键词: Blood pressure;Vasopressin;Vasopressin antagonist;Hypertension;Spontaneously hypertensive rat;Cerebrospinal fluid;Peptides;Hypothalamus

 

数据来源: Karger

 

摘要:

Intraventricular perfusion with a hypertonic sodium chloride solution elicits increases in cerebrospinal fluid vasopressin and blood pressure and a decrease in heart rate. The central peptide response was greatly reduced in the hypertensive rat. Central pretreatment with the vasopressin (V1) antagonist completely abolished the pressor response to hypertonic sodium chloride in the normotensive animal. Results suggest that a central vasopressin receptor may play a role in the control of blood pressure.

 

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