Studies of the acute inhalation toxicity of lithium combustion aerosols were undertaken to aid in evaluating the health hazards associated with the proposed use of lithium metal in fusion reactors. A system was developed to generate lithium combustion aerosols by sweeping vapor from molten lithium metal into a controlled air atmosphere. Male and female F344ILov rats, 9–12 wk of age, were exposed once for 4 h to concentrations of 2600, 2300, 1400, or 620 mg/m3of aerosol (MMAD= 0.69 μm, σg= 1.45) that was approximately 80% lithium carbonate and 20% lithium hydroxide to determine the acute toxic effects. Fourteen‐day LC50 values (with 95% confidence limits) of 1700 (1300–2000) mg/m3for the male rats and 2000 (1700–2400) mg/m3for the female rate were calculated. Clinical signs of anorexia, dehydration, respiratory difficulty, and perioral and perinasal encrustation were observed. Body weights were decreased the first day after exposure in relation to the exposure concentration. In animals observed for an additional 2 wk, body weights, organ weigh ts, and clinical signs began to return to preexposure values. Histopathologic examination of the respiratory tracts from the animals revealed ulcerative or necrotic laryngitis, focal to seg‐mental ulcerative rhinitis often accompanied by areas of squamous metaplasia, and, in some cases, a suppurative bronchopneumonia or aspiration pneumonia, probably secondary to the laryngeal lesions. The results of these studies indicate the moderate acute toxicity of lithium carbonate aerosols and will aid in the risk analysis of accidental releases of lithium combustion aerosols.