Comparison of growth‐induced resorption and denervation‐induced resorption on the release of [3H]tetracycline,45calcium, and [3H]collagen from whole bones of growing rats
作者:
L. Klein,
K. G. Heiple,
B. V. Stromberg,
期刊:
Journal of Orthopaedic Research
(WILEY Available online 1983)
卷期:
Volume 1,
issue 1
页码: 50-56
ISSN:0736-0266
年代: 1983
DOI:10.1002/jor.1100010107
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: Bone resorption;Immobilization;Bone mass;45Calcium;[3H]Tetracycline;[3H]Collagen
数据来源: WILEY
摘要:
AbstractThe major effect of immobilization during growth is a smaller bone mass induced by either an increased bone resorption or a decreased bone formation. Using a method of analyzing radioisotopic loss of [3H]tetracycline and [3H]collagen from bone prelabeledin vivo, we compared the amount of bone resorption due to immobilization with bone resorption induced by growth. One hind limb was denervated in growing male rats, 6 weeks of age, that had been chronically prelabeled with [3H]tetracycline,45calcium, and [3H]proline. The total radioactivity of the whole femur and tibia/fibula from the denervated limb was compared with that from bones of the control limb at 0, 1, 2, 4, and 8 weeks after denervation. The effect of growth on bone formation was measured by net increases in bone length, volume, and mass of matrix and mineral. Experimental bones had a significantly smaller volume and mass. Bone resorption was much greater during growth modeling than during denervation. The additional bone resorption induced by denervation was a small fraction (one‐fourth) of the resorption induced by growth. Denervation during growth resulted in less bone being formed due to a smaller gain in matrix and mineral mass as a result of a reduction in bone formatio
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