Peripheral neuropathy in spinocerebellar degenerations
作者:
J. G. McLeod,
W. A. Evans,
期刊:
Muscle&Nerve
(WILEY Available online 1981)
卷期:
Volume 4,
issue 1
页码: 51-61
ISSN:0148-639X
年代: 1981
DOI:10.1002/mus.880040110
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractNerve conduction studies have been performed in 19 subjects with hereditary spinocerebellar degenerations other than Friedreich ataxia. Clinically, they may be classified as olivopontocerebellar atrophy or cerebello‐olivary degeneration. In 9 patients, sensory conduction was abnormal, and in the whole group there was a significant impariment of sensory conduction and mild slowing of motor conduction in the lateral popliteal nerve. Sural nerve biopsies were performed on 5 patients. In 3 cases there was a mild to moderate reduction of myelinated fibers of all diameters; unmyelinated fibers were normal. In 1 patient from a kindred with a spinocerebellar degeneration in which the inheritance was autosomal dominant, neuropathological findings at autopsy confirmed the clinical diagnosis of the Menzel type of olivopontocerebellar atrophy; thee was degeneration of dorsal root ganglion and anterior horn cells as well as of myelinated fibers of all diameters in the sural nerv
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