Tolerance to the Anticonvulsant Effect of Clorazepate and Clonazepam in Mice
作者:
R. Scherkl,
Doxa Kurudi,
H.‐H. Frey,
期刊:
Pharmacology&Toxicology
(WILEY Available online 1988)
卷期:
Volume 62,
issue 1
页码: 38-41
ISSN:0901-9928
年代: 1988
DOI:10.1111/j.1600-0773.1988.tb01841.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
Abstract:The rate of development of tolerance to the benzodiazepines clorazepate and clonazepam against pentetrazole‐induced seizures in mice was compared. Treatment with clorazepate (0.1% solution as drinking water) for 21 days led to tolerance beginning at day 7. When mice were treated with clonazepam (0.5 mg/kg twice daily intraperitoneally), tolerance was evident already at the fourth day of treatment. Twenty‐four hours after cessation of treatment the seizure threshold was significantly decreased after treatment with both drugs. Clorazepate, a prodrug of the main metabolite of diazepam, desmethyldiazepam, regards further interest for anticonvulsant therapy because of a relatively slow onset of tolera
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