The effects of albumin supplementation on pulmonary function were studied in 94 injured patients of whom 46 received albumin. The 94 patients received an average of 14.5 transfusions, 9.2 L crystalloid, and 0.9 L plasma in the emergency room and operating room; 46 patients received an average of 31 gm albumin during operation and 150 gm/day for 5 days. Blood pressure (BP), pulse, CVP, wedge pressure (PWP), red cell (RBCV), and plasma volumes (PV), total serum proteins (TSP), serum albumin (SA), cardiac output (CO), the per cent inspired oxygen/arterial O2tension (FIO2/pO2), and the per cent of physiologic shunting in the lungs (p shunt) were noted serially following operation; only the first study on each patient was used for statistical correlations between the two groups.Albumin supplementation significantly (p=2/ pO2ratio and the p shunt were significantly deranged in albumin patients. The FIO2/pO2ratio averaged 0.62 ± 0.6 in the albumin patients, and 0.33 ± 0.1 in the nonalbumin-treated patients; the p shunt averaged 29 and 19%, respectively. The albumin patients required ventilatory support for an average of 7.7 days versus 2.9 days in the nonalbumin patients (p=