Functional Preservation of Benzodiazepine Receptors of the Primary Somatosensory Cortex in Creutzfeldt‐Jakob Disease: A Pharmacologic‐Evoked Potential Study
作者:
U. Aguglia,
R. Oliveri,
A. Gambardella,
G. Talerico,
M. Zappia,
G. De Sarro,
A. Quattrone,
期刊:
Clinical Neuropharmacology
(OVID Available online 1996)
卷期:
Volume 19,
issue 1
页码: 87-91
ISSN:0362-5664
年代: 1996
出版商: OVID
关键词: Creutzfeldt‐Jakob disease;Diazepam;Flumazenil;&ggr;‐Aminobutyric acid;Somatosensory evoked potentials.
数据来源: OVID
摘要:
Summary:In previous studies, we demonstrated that the benzodiazepine (BZP) receptors of the visual system are functionally preserved in Creutzfeldt‐Jakob disease (CJD). We hypothesized that such a functional preservation is not confined to the visual system. In a 74‐year‐old woman suffering from CJD, three consecutive recording sessions of somatosensory cortical evoked potentials (SEPs) by right median nerve stimulation were carried out: (a) basal condition, without any pharmacologic treatment; (b) 1 min after i.v. administration of 10 mg diazepam (DZP); (c) 2.5 min after i.v. administration of 3 mg FMZ, a high‐affinity receptor benzodiazepine antagonist. DZP greatly decreased the amplitude of SEP early components, whereas flumazenil (FMZ) reversed such an effect. The results of this study, paralleling our previous findings on the visual system in CJD, demonstrated functional preservation of BZP receptors in the somatosensory pathways as well.
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