Behavior of fish retinal growth cones encountering chick caudal tectal membranes: A time‐lapse study on growthcone collapse
作者:
Martin Bastmeyer,
Claudia A. O. Stuermer,
期刊:
Journal of Neurobiology
(WILEY Available online 1993)
卷期:
Volume 24,
issue 1
页码: 37-50
ISSN:0022-3034
年代: 1993
DOI:10.1002/neu.480240104
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: goldfish;regenerating axons;axonal guidance;in vitroassay;videomicroscopy
数据来源: WILEY
摘要:
AbstractIn a cross speciesin vitroassay, growth cones from fish temporal retina elongating on laminin lanes were observed with time‐lapse videomicroscopy as they encountered lanes and territories that carried membrane fragments from the chick caudal tectum. Caudal tectal membranes of adult fish and embryonic chick are known to possess a repellent guiding component for temporal retinal axons. The caudal membranes of chick exert a particularly strong influence on fish temporal axons. Contacts with chick caudal membranes by just a few filopodia and parts of the lamellipodia evoked a turning response away from the membrane lane of the entire growth cone. Contacts by filo‐ and lamellipodia over the entire circumference of the growth cone, however, caused invariably growth cone collapse and retraction. During growth cone turning and collapse and retraction, filopodia remained in contact with the tectal membrane fragments, suggesting strong membrane–filopodia adhesion simultaneous to growth cone repulsion by the repellent guiding component. © 1993 John Wiley&Son
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