Monocyte/Macrophage Regulation of Coagulant Events
作者:
Paula B. Tracy,
Debra H. Allen,
Laura A. Worfolk,
Royce Robinson Lawler,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1996)
卷期:
Volume 26,
issue 1
页码: 6-11
ISSN:1424-8832
年代: 1996
DOI:10.1159/000217230
出版商: S. Karger AG
关键词: Monocyte;Macrophage;Tissue factor;Factor V/Va;Prothrombinase;Laminin;Elastase;Cathepsin G
数据来源: Karger
摘要:
Monocytes/macrophages actively regulate both the assembly and function, as well as the substrate specificity, of various coagulation enzymes at their membrane surface. Regulation is effected through a variety of mechanisms, not limited to, but including the expression of receptors (or ‘binding sites’) for the various protein constituents of the complexes, the expression of different receptors which may alter the function of the protease, and the expression of membrane proteases which may affect protein cofactor function. Monocyte stimulation with various agonists modulates many of these responses as does their adherence to and differentiation on various substra
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