Seasonal Changes in the Sensitivity of Ovine Pineal β- Adrenoceptors to Steroids
作者:
Andrew Foldes,
Colin A. Maxwell,
Rex J. Scaramuzzi,
John B. Donnelly,
Ronald M. Hoskinson,
Allan J. Rintoul,
期刊:
Neuroendocrinology
(Karger Available online 1985)
卷期:
Volume 41,
issue 6
页码: 494-498
ISSN:0028-3835
年代: 1985
DOI:10.1159/000124225
出版商: S. Karger AG
关键词: Ovine pineal adrenoceptors;Gonadal Steroids;Immunoneutralization
数据来源: Karger
摘要:
Immunoneutralization of endogenous gonadal steroids has recently been shown to modify pineal β-adrenoceptor function in intact Merino ewes. In the current study, interactions between gonadal steroids and these receptors have been further investigated. β-Adrenoceptor density and binding affinity both showed time-related changes in ewes; the significance of these changes requires further study. Two observations, firstly modification of β-adrenoceptor function by androstenedione and 17β-estradiol in ovariectomized, but not in intact ewes, and secondly that steroid-mediated effects on receptor density and binding affinity in the pineal of ovariectomized Merino ewes could be demonstrated during anestrus, but not during the breeding season for intact ewes, indicate that gonadal steroids may regulate pineal β-adrenoceptor variables in Merino ewes. It is suggested that gonadal steroids may regulate ovine pineal function in ewes, and that the seasonal differences in sensitivity of luteinizing hormone release to steroid feedback may be mediated in part via effects on the pineal g
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