Treatment of Cytomegalovirus Diseases
作者:
Jens-Owe Vogel,
Martin Scholz,
Jindrich Cinatl, Jr.,
期刊:
Intervirology
(Karger Available online 1997)
卷期:
Volume 40,
issue 5-6
页码: 357-367
ISSN:0300-5526
年代: 1997
DOI:10.1159/000150568
出版商: S. Karger AG
关键词: Human cytomegalovirus;Antiviral therapy;New drugs
数据来源: Karger
摘要:
This review summarizes current strategies for the treatment of human cytomegalovirus (CMV) infection/diseases in high-risk patients such as transplant recipients and AIDS patients. Since the major drugs ganciclovir (Cytovene), foscarnet (Foscavir) and cidofovir (Vistide) are frequently associated with severe side effects and the formation of viral resistance, it should be endeavored to develop better strategies in anti-CMV treatment. Moreover, blocking of the viral replication does not always resolve the manifestations which are often linked with CMV-associated immunopathomechanisms. Thus, the efficacy of the available drugs is also discussed in the light of their ability to modulate inflammatory components of the cell-mediated immune system.
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