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The Influence of Gangliosides on Serotonin Binding and Uptake by Human Platelets

 

作者: VasylevskayaV. V.,   ZvezdinaN. D.,   KorotaevaA. A.,   ProkazovaN. V.,  

 

期刊: Platelets  (Taylor Available online 1995)
卷期: Volume 6, issue 1  

页码: 37-42

 

ISSN:0953-7104

 

年代: 1995

 

DOI:10.3109/09537109509013260

 

出版商: Taylor&Francis

 

数据来源: Taylor

 

摘要:

It has been shown that gangliosides exert an influence on serotonin (5-HT) binding and uptake by human platelets. The effect depends on ganglioside structure. In particular, GT1b increases the number of 5-HT binding sites by 40 to 60%, and GM1, GM3 and GD3 decrease it by 20 to 40%. None of the gangliosides tested influences the affinity of the 5-HT binding sites with KD= 60±10 nM. It has been found that loading platelets with GT1b increases the rate of 5-HT uptake and increases the capacity of platelets for this monoamine. It is concluded that gangliosides incorporated into platelet membranes influence the number of 5-HT binding sites on the serotonin transporter.

 

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