The Influence of Gangliosides on Serotonin Binding and Uptake by Human Platelets
作者:
VasylevskayaV. V.,
ZvezdinaN. D.,
KorotaevaA. A.,
ProkazovaN. V.,
期刊:
Platelets
(Taylor Available online 1995)
卷期:
Volume 6,
issue 1
页码: 37-42
ISSN:0953-7104
年代: 1995
DOI:10.3109/09537109509013260
出版商: Taylor&Francis
数据来源: Taylor
摘要:
It has been shown that gangliosides exert an influence on serotonin (5-HT) binding and uptake by human platelets. The effect depends on ganglioside structure. In particular, GT1b increases the number of 5-HT binding sites by 40 to 60%, and GM1, GM3 and GD3 decrease it by 20 to 40%. None of the gangliosides tested influences the affinity of the 5-HT binding sites with KD= 60±10 nM. It has been found that loading platelets with GT1b increases the rate of 5-HT uptake and increases the capacity of platelets for this monoamine. It is concluded that gangliosides incorporated into platelet membranes influence the number of 5-HT binding sites on the serotonin transporter.
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