Roles of endothelial dysfunction in coronary artery disease
作者:
Marc Forgione,
Jane Leopold,
Joseph Loscalzo,
期刊:
Current Opinion in Cardiology
(OVID Available online 2000)
卷期:
Volume 15,
issue 6
页码: 409-415
ISSN:0268-4705
年代: 2000
出版商: OVID
数据来源: OVID
摘要:
Endothelial dysfunction is an early and persistent vascular abnormality in the evolution of atherothrombotic disease. Risk factors for atherosclerosis promote an inflammatory oxidative environment in the vasculature that induces pathologic changes in endothelial function, including the support of enhanced smooth muscle tone, thrombosis, and smooth muscle proliferation. This article provides an overview of the molecular basis of endothelial dysfunction and of its diagnosis and treatment.
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