Possible Role of Alpha-2-Noradrenergic Receptors in Modulation of Sexual Behavior in Female Guinea Pigs
作者:
Patricia A. Vincent,
Janice Thornton,
Harvey H. Feder,
期刊:
Neuroendocrinology
(Karger Available online 1987)
卷期:
Volume 46,
issue 1
页码: 10-13
ISSN:0028-3835
年代: 1987
DOI:10.1159/000124790
出版商: S. Karger AG
关键词: Lordosis;Methoxamine;Phenylephrine;Clonidine;Idazoxan;Yohimbine;Sexual behavior;Guinea pig;Noradrenergic
数据来源: Karger
摘要:
These studies examine whether αi-noradrenergic receptor stimulation alone is sufficient to facilitate lordosis behavior in ovariectomized, estrogen-primed female guinea pigs and to what extent α2-noradrenergic receptors are involved in this steroid-dependent behavior. Neither of the α1-agonists, phenylephrine or methoxamine, significantly facilitated lordosis in ovariectomized females primed with 10 µg of estradiol benzoate for 1 or 3 days. Animals exhibiting estrogen plus clonidine-facilitated lordosis showed a decrease in the behavior when given one of two α2-antagonists (yohimbine or idazoxan). Idazoxan also attenuated lordosis in animals given estrogen plus progesterone. These findings, in combination with previous findings (that specific α1-antagonists block lordosis), suggest that α2-receptors, in addition to α1-receptors play a role in modulation of lordosis b
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