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The Effects of 6R-L-Erythro-5,6,7,8-Tetrahydrobiopterin on Ethanol-Induced Sleep Time a...
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The Effects of 6R-L-Erythro-5,6,7,8-Tetrahydrobiopterin on Ethanol-Induced Sleep Time and Ethanol Elimination in Inbred Strains of Mice with Different Alcohol Preference
作者:
K. Yoshimoto,
T. Yoshida,
Y. Takeuchi,
S. Ueda,
期刊:
Neuropsychobiology
(Karger Available online 1997)
卷期:
Volume 36,
issue 4
页码: 188-193
ISSN:0302-282X
年代: 1997
DOI:10.1159/000119382
出版商: S. Karger AG
关键词: Tetrahydrobiopterin;Ethanol;Sleep time
数据来源: Karger
摘要:
6R-L-erythro-5,6,7,8-tetrahydrobiopterin (6R-BH4) is a coenzyme for tyro-sine, tryptophan and phenylalanine hydroxylases. Male C57BL/6J and DBA/ 2J mice were given 6R-BH4 (0,12.5, 25.0 and 50.0 mg/kg of body weight, i.v.) or saline, and then 4 h later, all animals were injected with ethanol (EtOH) (4.0 g/kg, i.p.), which causes them to lose the righting reflex, to investigate the differences in EtOH-induced sleeping time. 6R-BH4 pretreatment reduced EtOH-induced sleep time in DBA/2J mice with lower alcohol preference (p < 0.05), which showed no changes in the pharmacokinetics of blood EtOH. No changes in EtOH-induced sleep time were observed in C57BL/6J mice with higher alcohol preference. These results indicate that the sensitivity to EtOH in mice with lower alcohol preference was associated with 6R-BH4 activity in the CNS.
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